Spinal Cord Regeneration with Olfactory Mucosa Autografts
نویسندگان
چکیده
منابع مشابه
Olfactory mucosa autografts in human spinal cord injury: a pilot clinical study.
BACKGROUND/OBJECTIVE Olfactory mucosa is a readily accessible source of olfactory ensheathing and stem-like progenitor cells for neural repair. To determine the safety and feasibility of transplanting olfactory mucosa autografts into patients with traumatically injured spinal cords, a human pilot clinical study was conducted. METHODS Seven patients ranging from 18 to 32 years of age (American...
متن کاملOlfactory mucosa transplantation for spinal cord injury.
Carlos Lima et al. who are pioneers in this field reported their clinical pilot study of olfactory mucosa transplantation for chronic spinal cord injury. They showed the safety and feasibility of it. Olfactory mucosa contains the olfactory ensheathing cells and neural stem cells. Recent studies have demonstrated the potential therapeutic role of both cells in spinal cord injury. We have already...
متن کاملTransplantation of Olfactory Mucosa as a Scaffold for Axonal Regeneration Following Spinal Cord Contusion in Rats
Object: The inability of the spinal cord to regenerate after SCI is due to the extremely limited regenerative capacity of most central nervous system (CNS) axons, along with the hostile environment of the adult CNS, which does not support axonal growth. It seems that for successful axonal regeneration to take place, a supportive local environment is required after the injury. We have previously...
متن کامل[Olfactory mucosa autograft for chronic complete spinal cord injury].
UNLABELLED The efficacy of olfactory mucosa autograft (OMA) for chronic spinal cord injury has been reported. New activity in response to voluntary effort has been documented by electromyography (EMG), but the emergence of motor evoked potential (MEP) reflecting electrophysiological conductivity in the central nervous system, including the corticospinal pathway after OMA has not been clarified....
متن کاملOlfactory mucosal autografts and rehabilitation for chronic traumatic spinal cord injury.
BACKGROUND/OBJECTIVE Basic science advances in spinal cord injury (SCI) are leading to novel clinical approaches. The authors report a prospective, uncontrolled pilot study of the safety and outcomes of implanting olfactory mucosal autografts (OMA) in 20 patients with chronic, sensorimotor complete or motor complete SCI. METHODS Seven paraplegic and 13 tetraplegic subjects (17 men and 3 women...
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ژورنال
عنوان ژورنال: Japanese Journal of Neurosurgery
سال: 2013
ISSN: 0917-950X,2187-3100
DOI: 10.7887/jcns.22.452